Tris Pharma Technology Overview

What makes Tris unique?

Short video providing an overview of Tris Pharma’s proprietary LiquiXR^® technology, which was used in the development of Tris Pharma’s branded ADHD products.

LiquiXR drug delivery technology utilizes an ion-exchange resin

• Ion-exchange resins are made of negatively charged, polystyrene.
• Any active moiety that can be protonated and is water-soluble can complex with the ion-exchange resin to form micron-sized drug-resin particles.

Drug-resin particles can be coated with a polymer of varying thickness

• Portions of drug-resin particles can be coated with an aqueous polymer that allows for passive ion-exchange with NO pH-dependent breakdown required.
• Polymer coating applied to drug-resin particles is of varying thickness which allows for programmed, extended release of active drug product.
• These micron-sized, drug-resin particles can be formulated into a variety of dosage forms (tablets, liquids, films, capsules).

Millions of immediate-release and extended-release particles enable targeted pharmacokinetic profiles

• Solid, uncoated particles provide for immediate-release of active drug product.
• The variable thickness of the polymer-coated particles allows for programmed, extended release of active drug product.

Active drug moiety is released from the drug-resin particles via ion exchange and diffusion

• Once ingested, positively charged ions from the gastrointestinal tract, like sodium, diffuse across the polymer coating and displace the drug from the resin.
• The drug then diffuses back across the coating to the gastrointestinal tract.

Extended-release coating of variable thickness slows the diffusion of ions entering and exiting the particles

• The extent of drug release is based on diffusion rate across the polymer coating which is NOT pH-dependent.
• The mechanism of drug release allows for rapid absorption and sustained plasma levels after once-daily dosing.
• Technology allows for development of customizable release profiles.
• Release profiles can last up to 24 hours.
• The ion-exchange resins are excreted unchanged in the feces.