Short video providing an overview of Tris Pharma’s proprietary LiquiXR® technology, which was used in the development of Tris Pharma’s branded ADHD products.
Overview of Tris Pharma technology used in Tris’ ADHD products.
Tris Pharma LiquiXR® Technology
What is LiquiXR® Technology?
LiquiXR® drug delivery technology utilizes an ion-exchange resin
- Ion-exchange resins are made of negatively charged, polystyrene.
- Any active moiety that can be protonated and is water-soluble can complex with the ion-exchange resin to form micron-sized drug-resin particles.
Drug-resin particles can be coated with a polymer of varying thickness
- Portions of drug-resin particles can be coated with an aqueous, pH-independent polymer
- Polymer coating applied to drug-resin particles is of varying thickness
- These micron-sized, drug-resin particles can be formulated into a variety of dosage forms (tablets, liquids, films, capsules)
Millions of immediate-release and extended-release particles enable targeted pharmacokinetic profiles
- Solid, uncoated particles provide for immediate-release of active drug product.
- The variable thickness of the polymer-coated particles allows for programmed, extended release of active drug product.
Active drug moiety is released from the drug-resin particles via ion exchange and diffusion
- Once ingested, positively charged ions from the gastrointestinal tract, like sodium, diffuse across the polymer coating and displace the drug from the resin.
- The drug then diffuses back across the coating to the gastrointestinal tract.
Extended-release coating of variable thickness slows the diffusion of ions entering and exiting the particles
- The extent of drug release is based on diffusion rate across the polymer coating which is pH-independent
- The mechanism of drug release allows for rapid absorption and sustained plasma levels after once-daily dosing
- Technology allows for development of customizable release profiles
- Release profiles can last up to 24 hours
- The ion-exchange resins are excreted unchanged in the feces
For more information about LiquiXR® technology, please click here.